Given the role of miRNAs in autoimmune diseases, particularly RA, we investigated miRNA variants (rs2292832, rs3746444, rs11614913, rs1044165, and rs767649 of MIR149, MIR499, MIR196, MIR223, and MIR155, respectively) for their association with the risk of RA in the Pakistani population. This evidence concerns the gene MIR499A and rheumatoid arthritis.