Additionally, studies have reported the increased expression of IFN-γ-related genes in the liver of PBC patients [64], increased expression of IFN-α/IFN-β and IFN-γ in lesions of PBC liver [65], and the appearance of PBC-like liver lesions in female mice with chronic expression of IFN-γ [66]. The gene discussed is IFNG; the disease is primary biliary cholangitis.