This study identified 22 novel PBC susceptibility gene loci (nearest genes: FCLR3, CACNA1S, LINC00299, DNMT3A, TMEM163, RARB, TET2, ST8SIA4, NDFIP1, ATG5, CCR6, ITGB8, ZC3HAV1, MYC, ANP32B, WDFY4, DEAF1, ETS1, SRP54, RIN3, DPEP2, and CD226 on autosomes, and GRIPAP1 on the X chromosome) (Table 1) [44,45]. The gene discussed is TMEM163; the disease is primary biliary cholangitis.