CD28 and primary biliary cholangitis: Additionally, other GWASs identified 14 (nearest genes: CD58, STAT4, CD28, TIMMDC1, IL12A, NFKB1, IL7R, HLA, TNFSF15, POU2AF1, CXCR5, IL21R, IKZF3, and SYNGR1) PBC susceptibility loci in East Asian populations (Table 1) [40,41,42,43].