CD28, which was reported as a susceptibility locus for lymphocyte and eosinophil counts, multiple sclerosis, ulcerative colitis, celiac disease, rheumatoid arthritis, asthma, and PBC, has a shared disease-related primary functional variant (i.e., rs2013278) that regulates the CD28 alternative splicing that generates loss-of-function isoforms (CD28i and CD28∆ex2) [61]. The gene discussed is CD28; the disease is celiac disease.