GIRK2, which forms channels together with GIRK3, has been associated with neurological disorders in model animals and in humans: spontaneous seizures have been described in GIRK2-/- and GIRK2.3-/- knockout mice [36,38], and in humans variants in the KCNJ6 gene cause Keppen–Lubinsky syndrome, a severe hyperkinetic disorder (https://www.omim.org/entry/600877, accessed on 12 October 2022). Here, KCNJ6 is linked to Keppen-Lubinsky syndrome.