HSPA4 and cancer: This is also consistent with the work of Singh & Suri [22] on RCC, who demonstrated that the knockdown of the HSP70 gene resulted in the reduction of cellular proliferation and cancer aggressiveness and that of Dall’Oglio et al. in clear-cell type RCC who found high expression level of HSP70 with metastatic RCC than in low-and-moderate grade cancer [42].