Based on these results, the present study aims, in a sample of first episode psychosis patients, to explore whether a higher depression at the onset was found in those who: (1) had at least one major stressful event in the previous 6 months; and (2) were homozygous for the COMT Val158 allele or carrying the S allele of 5-HTTLPR. Here, COMT is linked to major depressive disorder.