Proteomic studies of CSF-derived EV cargo revealed that several proteins such as TDP-43, NIR, NOC2L, PDCD6IP, VCAN, and BLHM were increased and SERPINA3, PTPRZ1, C1QC, CCDC19, MYL6B, MARCO, FCGBP, FOLR1, RELN, CFB, and CHMP4A were decreased, indicating their potential role in ALS pathogenesis [116,121]. Here, RELN is linked to amyotrophic lateral sclerosis.