The main genes associated with ALS pathogenesis are copper- and zinc-containing antioxidant superoxide dismutase 1 (SOD1), TAR DNA-binding protein 43 (TARDBP, also known as TDP43), fused in sarcoma (FUS), optineurin (OPTN), valosin-containing protein (VCP), ubiquilin 2 (UBQLN2), C9ORF72, and profilin 1 (PFN1). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.