Susceptibility to a broad range of triggers, including emotions, fever, high external temperature, infections, and intentional movements causes life-threatening paroxysmal exacerbations and is pathognomonic for GNAO1 encephalopathy and other postsynaptic disorders caused by mutations in genes with a role in this pathway (i.e., ADCY5, GNB1, HPCA, PDE2A, and PDE10A) [13,14]. Here, GNAO1 is linked to Encephalopathy.