HSPH1 and malignant colon neoplasm: In the ATM, MRE11 and HSP110 genes, the exon skipping phenomenon is always detected at given frequencies, leading to various degrees of impairment of the protein activity or in the production of a chaperone Hsp110 isoform, permitting better responses to 5-fluorouracile in this subset of colon cancer patients [34,35].