Gastric cancers also show MSI-associated alterations, including in intron 4 of the MRE11 gene [31], and many additional splice site mutations accompanied by aberrant splicing products were also identified, including in the FHIT (Fragile Histidine Triad Diadenosine Triphosphatase) gene, a putative tumor suppressor gene [38]. The gene discussed is FHIT; the disease is neoplasm.