CSNK2B and Craniodigital syndrome - intellectual disability: In this regard, two CSNK2B missense mutations, the p.Asp32Asn that was originally identified in POBINDS patients, and p.Asn32His, have been recently proposed as the cause of a new intellectual disability-craniodigital syndrome (IDCS) distinct from POBINDS and characterized by cranial anomalies, facial dysmorphisms and digital anomalies.