Despite the heterogeneity of the clinical data and the small number of patients, this comparison highlights some overlapping features, such as facial characteristics, skeletal and cardiovascular abnormalities and an abnormal number of teeth, in addition to ID, epilepsy and language impairment, and this suggests the existence of a continuous spectrum of CSNK2B-associated phenotypes, rather than a sharp distinction between them. This evidence concerns the gene CSNK2B and epilepsy.