Other studies showed the increased transcript of genes involved in synaptic plasticity: calcyon, a protein potentiating crosstalk between the D1 dopamine receptor and Gq-11-links receptor, and spinophilin, a protein enriched in dendritic spines and modulating excitatory neurotransmission [64], and also downregulation of synaptogyrin 1 (SYNGR1) and synaptogamin (SYT11) regulated presynaptic plasticity the PFC of patients with schizophrenia [65]. This evidence concerns the gene DRD1 and schizophrenia.