INS and type 2 diabetes mellitus: Adipokines (i.e., cytokines secreted by adipose tissue) reflect adipose tissue endocrine function as it relates to metabolic homeostasis [9,10] and, compared with traditional risk markers such as glycaemia or insulin, may provide better risk assessment in T2D in relation to cardiovascular health, oxidative stress, energy systems behavior, visceral fat, chronic inflammation, and comorbidities [10].