It is suggested that the term CRMS be used to refer to newborns with hypertrypsinogenemia on the NBS who have sweat chloride readings <60 mmol/L and up to two CFTR variants, at least one of which is not characterized as a CF-disease-causing variant, and who do not match the criteria set out by the CF Foundation for the diagnosis of CF [2]. The gene discussed is CFTR; the disease is cystic fibrosis.