In contrast, in LPS-exposed sheep the inflammation inhibited vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), platelet endothelial cell adhesion molecule-1, and Tie-2 protein, which led to vascular remodeling in small pulmonary arteries causing pulmonary hypertension [75]. Here, NOS3 is linked to pulmonary hypertension.