Metabolic inflammation is defined as the sustained, low-grade activation of different inflammatory molecules, including interleukin, C-reactive protein (CRP), tumor necrosis factor-alpha (TNFα), fibrinogen, and others, registered in over-nutrition-related pathologies such as obesity and type 2 diabetes [91,92,93]. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.