Indeed, different genetic variants (e.g., the I148M allele of the Patatin-like phospholipase containing domain 3 (PNPLA3), the E167K allele of the Transmembrane 6 superfamily member 2 (TM6SF2), the hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13), the rs1260326 in the glucokinase regulatory protein (GCKR), and the Membrane bound O-acyltransferase domain containing 7-transmembrane channel-like 4 (MBOAT7-TMC4) genes have been mainly linked to NAFLD development and progression. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.