This systematic review evaluated the association of DEFB1 (rs11362, rs1799946, and rs1800972) and MBL2 (rs7096206 and rs1800450) polymorphisms with DC risk; the findings suggest that DEFB1 rs11362 polymorphism in T allele is related to an increased likelihood of DC occurrence. Here, MBL2 is linked to dyskeratosis congenita.