Alchujyan et al. [50] also observed differences in NOS activities in peripheral blood leukocyte cells in a group of children/adolescents and young adults with type 1 diabetes (T1D) and observed that several factors affect bioavailable NOx, which include not only glycemic status and duration of T1D but also age and sex. The gene discussed is NOS2; the disease is type 1 diabetes mellitus.