For example, mutations in FOXC1 (forkhead box transcription factor C1) and PITX2 (paired-like homeodomain transcription factor 2) were found in Axenfeld–Rieger syndrome [36,37]; genotype–phenotype mutations in PAX6 (paired box 6) were found to be associated with aniridia [38]. This evidence concerns the gene PITX2 and aniridia.