Biomarkers for colorectal, lung, and prostate cancers include the estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), anaplastic lymphoma kinase (ALK), and Kirsten rat sarcoma (KRAS).The bone and muscle cancers have breast cancer genes 1 and 2 (BRCA1 and BRCA2), echinoderm microtubule-associated protein-like 4 (EML4), and carcino-embryonic antigen (CEA) as their biomarkers. The gene discussed is ESR1; the disease is muscle cancer.