Finally, we hypothesized that three factors are the most important ones to decrease the number of officially reported deaths in Brazil: (a) increase the number of reference centers and the availability of sweat tests—including in regions with low population density and low incidence of White individuals per 1000 inhabitants; (b) implementation of neonatal screening for CF in neonatal screening tests in Brazil; and (c) higher accessibility of genetics tests to confirm the CF diagnoses mainly for those patients with the rarest pathogenic variants in the CFTR gene. Here, CFTR is linked to cystic fibrosis.