Although this study did not investigate the performance when combining CXCL10 and IFNG mRNA, it demonstrated the benefit of combining suitable mRNA markers, such as IFNG, TNFα and IL-2R or TNFα, IL-2R, CXCL9, and CXCL10, to improve TB diagnosis and differentiate Mtb infection status [15]. Here, TNF is linked to tuberculosis.