There was also no difference in the distribution of the following factors: gender, body mass index (BMI), previous coronary artery disease, cardiovascular risk factors (diabetes, smoking, hypertension, heredity, and dyslipidaemia), presence of severe mitral regurgitation (MR), levels of peak high-sensitivity cardiac troponin I, medication (i.e., beta blockers, diuretics, and nitrates), E-deceleration time, mitral regurgitant orifice area, or mitral regurgitant volume. This evidence concerns the gene TNNI3 and mitral valve insufficiency.