Through the coupling of genes in the p-metaomic models, our analysis highlights the significance of (a) FANCD2, NABP2 (hSSB1), and SPINK1 genes; (b) xenobiotic metabolism, bicarbonate transport, transcription, glycosylation, digestion, and developmental-related processes, as well as nuclear and mitochondrial DNA repair processes; and (c) TFs, such as HNF1, ALX1, AR, and GR, and (d) miR-143, miR-17-3P, miR-380-3P, and miR-29 family in NSCLC. The gene discussed is FANCD2; the disease is non-small cell lung carcinoma.