The majority of the radiogenomic studies in NSCLC focus on the prediction of oncogenic mutations, such as the epidermal growth factor receptor (EGFR) and the Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations, solely from the non-invasive radiomic features [9,10,11,12,13,14]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.