About 85% of EOC patients have elevated levels of CA-125; however, high serum levels of CA-125 can also be indicative of other gynaecological diseases such as endometriosis, liver cirrhosis, uterine fibroids, gastrointestinal cancer, etc., thereby limiting its specificity and sensitivity to some extent [10]. Here, MUC16 is linked to uterine corpus leiomyoma.