CD68 and melanoma: For instance, benign granular cell tumors are positive for S-100 protein, CD63, CD68 and neuron-specific enolase whereas atypical fibroxanthoma stains negatively for S100 protein, Melan-A, human melanoma black (HMB)-45 pan-cytokeratin (CK) and actin and positively for CD68 and vimentin [87].