Montemayor et al. reported [31] in a study on 128 patients aged 40–60 years with BMI between 27 and 40 kg/m2, with diagnosis of NAFLD and MetS, that conventional diet (CD) 43 patients, Mediterranean Diet (MD)—high meal frequency, 43 patients, and MD—physical activity (PA), 42 patients, decreased the intrahepatic fat content and liver stiffness alongside with BMI, insulin, HbA1c, diastolic BP, HDL-C and ALT after 12 months as seen in Table 1. This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.