CD4 and non-alcoholic fatty liver: NAFL progresses to NASH when evidence of hepatocellular injury characterized by the presence of lobular inflammation (mixture of CD4-(+), CD8-(+) lymphocytes, Kupffer cell aggregates, polymorphonuclear leukocytes, macrophages, T-cells), hepatocellular ballooning degeneration, apoptotic bodies, and Mallory-Denk bodies (eosinophilic intracytoplasmic inclusion composed of misfolded filaments of keratins, heat-shock proteins) [41] can be seen on histology samples [17].