A fatty liver overproduces glucose and lipids, especially very low-density lipoproteins (VLDL), the main players of MetS, but also the majority of the well-known CV risk factors, including fibrinogen, C-reactive protein (CRP), plasminogen activator inhibitor-1 (PAI-1) and coagulation factors [15,16]. This evidence concerns the gene SERPINE1 and metabolic syndrome.