In a case report by Ballal et of a 31-year-old female with metastatic ER-, PR- and HER 2+ breast cancer with disease progression on standard lines of therapy and intense radiotracer accumulation was noted in all the lesions on 177Lu-DOTATATE dosimetry images in concordance to 68Ga-DOTA-FAPi PET/CT scans [88]. This evidence concerns the gene ESR1 and breast cancer.