ΔppGpp) showed tumor: normal organ bacterial ratio of over 10,000:1, with bacterial cells reaching 1 × 107 CFU/g in tumor 3 days after intravenous injection [8,9], and cause various anticancer immune responses, including recruiting immune cells and secretion of proinflammatory cytokines, such as IFN-γ, TNF-α, and IL-1β [10,11,12,13]. Here, IL1B is linked to neoplasm.