MAPT and Alzheimer disease: While many factors may contribute to AD etiology [4,5], including inflammation [11,12,13,14] and microbial infection [6,15,16], the misfolding and aggregation of Aβ and tau into fibrillar amyloid aggregates is still recognized as a central pathogenic event and one that is believed to occur decades before the onset of neurodegeneration and cognitive impairment [1,17,18,19].