After Arc and NR2B overexpression in the hippocampus of migraine mice was blocked, the expression of SYP and AMPAR was restored; the number of dendritic spines in hippocampal neurons, the number of presynaptic membrane vesicles, and the thickness of postsynaptic membrane PSD were restored to levels comparable to those of the control group; and the animals’ recognition and memory abilities were meaningfully higher than those of the IS. This evidence concerns the gene ARC and migraine disorder.