The pathophysiological mechanism of acute small-vessel ischemic stroke is also different from other types of cerebral infarction, while the possible pathogenesis of lacunar infarction includes hypertensive arteriosclerosis, atherosclerotic plaque, and an inflammatory response (TNF-, IL-6) [67], which have been shown to be associated with visceral adiposity [16,52,53,68]. The gene discussed is TNF; the disease is cerebral infarction.