Moreover, CDC42 and RHOA serve as key modulators in the cascade of ischemic stroke involving apoptosis, excitotoxicity, platelet function, neuroinflammation, and blood–brain barrier (BBB) balance [13,14,15,16], emphasizing CDC42 and RHOA as key endogenous mediators in the penumbra. The gene discussed is CDC42; the disease is ischemic stroke.