Pan and colleagues showed that estradiol’s neuroprotective effect against amyloid pathology in AD is potentially mediated by the miR-106b-5p/TXNIP axis in a neuroblastoma cell line [139], while another study showed that estradiol treatment on ovarectomized AD model mice slowed the pathological conformational changes of tau. The gene discussed is TXNIP; the disease is Alzheimer disease.