BIRC5 and central nervous system cancer: Additionally, knockdown of the expression of BIRC5 (Spearman’s coefficients = 0.939, p < 0.001) and RRM2 (Spearman’s coefficients = 0.936, p < 0.001), two additional top 50 TK1-associated coexpressed positive genes, inhibits the migration, proliferation, and apoptosis of glioma cells [46,47].