A role in a wide variety of cellular functions including transcription regulation, insulin signaling, and secretion. MICPCH is also considered a neurodevelopmental disorder that occurs due to heterozygous mutations in gene CASK in girls. Some missense CASK mutations in boys are milder and are usually found in cases of X-linked mental retardation in normocephalic boys. This evidence concerns the gene CASK and neurodevelopmental disorder.