The number of CD163+ macrophages differed among secreting PA groups (p = 0.003), and a post hoc analysis showed that the quantity of CD163+ macrophages in GH-secreting adenomas was higher than that in prolactinomas (p = 0.0003), ACTH-secreting adenomas (p = 0.007), non-functional adenomas (p = 0.004), and plurihormonal-secreting adenomas (p = 0.003). This evidence concerns the gene POMC and adenoma.