Among the agents tested, there are those that increase the transcription, translation, and secretion of BDNF, with these including gene therapy using viruses as vectors, the administration of plasmid DNA encoding BDNF using nanoparticles, or the use of ECB employed in the treatment of epilepsy with genetically modified human cells designed to release BDNF [5,10,52,122,123,124]. Here, BDNF is linked to epilepsy.