This suggests that VEGF with Tie2 signalling could stimulate sprouting angiogenesis in BRCA-related cancer, accounting for the high microvessel density often observed in these cancers (especially the triple-negative/basal-type breast cancer common in BRCA1 carriers) and suggest these breast tumours might be attractive targets for anti-angiogenic therapeutics. The gene discussed is VEGFA; the disease is breast cancer.