Furthermore, in ovarian cancer cells lines, dual blockade of PI3K and PARP in vitro resulted in downregulation of PI3K/AKT/mTOR signalling and impaired DNA damage response with HRR deficiency, with associated reductions in BRCA, in a setting of intact PIK3CAwt and BRCAwt [113,114,115]. The gene discussed is PARP1; the disease is ovarian carcinoma.