CD8A and cancer: Interestingly, this is somewhat different to what in seen in prostate cancer, where BRCA2mut tumours showed increased ratios of intratumoral to extratumoral immune cells, and lower CD8:FOXP3 ratios when compared with BRCA1mut and ATMmut cancers, suggestive of at least the possibility of a more suppressed microenvironment in some tumour types when stratified by BRCA mutation status [129].