Several study limitations were noted, however, and although there was high concordance between germline and tumour BRCA1/2mut, with 82.6% LOH of BRCA1/2, there was unknown methylation status of BRCA1/2 wild-type (wt) and HRR genes, and a lack of power due to small patient numbers in some subgroups. The gene discussed is BRCA1; the disease is neoplasm.