While only a small proportion of these BRCA1-like tumour harboured BRCA1 germline mutation, the finding that FOXM1 and downstream factors CDK4/6 are highly expressed in BRCA1-like tumours may have predictive implications in the setting of available CDK4/6-based therapies in BRCA1/2mut cancers. The gene discussed is CDK4; the disease is neoplasm.