Not surprisingly, compared with the general population, both BRCA1- and BRCA2-associated tumours showed higher mean RS scores (oncotype DX® 23.5-29 vs. 16) in 32 and 33 patients (25 BRCA2 and 8 BRCA1) [98,99] or a higher proportion of intermediate (18–30) or high (>30) RS scores (BRCA1—87.6%, BRCA2—82.8% vs. general population—46.6%, p < 0.001). The gene discussed is BRCA1; the disease is neoplasm.