BRCA1 and breast neoplasm: While not specifically looking at familial cancers, a study by Takada et al. [37] examined breast tumours with BRCA1 or BRCA2 alterations (methylation and/or loss or uniparental disomy) and showed significant associations with higher numbers of genomic aberrations and higher percentage of TP53 alterations than BRCA1/2wt tumours.