IDH2 and astrocytoma (excluding glioblastoma): Arranged from best to worst prognosis, LGGS can be fundamentally ordered into (A) IDH-mutant (IDHmt) LGGs with 1p/19q chromosomal codeletion, e.g., oligodendrogliomas, which are associated with gene mutations of Telomerase Reverse Transcriptase (TERT); (B) IDHmt LGGs without 1p/19q chromosomal codeletion, e.g., astrocytomas that are typically associated with mutations in Tumor Protein 53 (TP53) and ATP-Dependent Helicase ATRX (ATRX); and (C) IDH wild-type (IDHwt) LGGs [14].