The other two androgen-independent EA PCa cell lines, 22Rv1 and PC-3, expressed both PIK3CD-L and PIK3CD-S. The AA PCa cell line RC77 T/E (derived from a primary tumor) expressed very low levels of the PIK3CD-L and PIK3CD-S transcripts. The gene discussed is PIK3CD; the disease is posterior cortical atrophy.