CD8A and neoplasm: Thus, for example, when T-cell subtypes were compared in tumor-draining lymph nodes from cervical adenocarcinoma (ADC), there was a greater presence of T-cells, with a predominance of Tregs cells, CD8+ T-cells with a higher ‘exhaust’ profile, higher levels of CD8+ central memory T-cells (TMC CD27+CD45RA−), and CD8+ effector memory T-cells (TEM CD27−CD45RA−) than was the case with cervical squamous cell carcinoma (SCC) [110].