E-cadherin has been shown to be important for polarization and the release of cytotoxic granules used by CD8+ cytotoxic T-cells for killing tumor cells, which are stimulated by the interaction between integrin αE (CD103) β of tumor-infiltrating T-cells and E-cadherin of tumor cells [144,145,146,147,148]. Here, ITGAE is linked to neoplasm.