HSPA5 and lung cancer: The proteins belonging or closely associated with the heat-shock protein (HSP) family, folding, and structural assembly were identified as serotonylation targets, including PSMD9 (a chaperon for 26S proteasome assembly), heat-shock proteins such as DNJB1 (Hsp40) and GRP78 (HspA5), as well as radixin, RanBP-1, etc. All of these elements have varying degrees of interactions with the elements related to Akt signaling and subsequently lung cancer.