The effect of TGM2 on cell death, however, appears to be dependent on its localization and activation, as during apoptosis, the enzyme migrates from the cytosol to the nucleus to initiate transcription, a behavior that leads to the direct modulation of transcriptional activity in neurodegenerative diseases, likely as a consequence of direct Rb interaction [28] (Figure 2, purple arrows), which lead to Rb to sustain its antiapoptotic transcriptional activity. The gene discussed is RB1; the disease is neurodegenerative disease.