Inflammatory responses occur at the early stage after LITs, increasing the permeability of tumor vessels and promoting the injured tumor cells to produce chemokines (e.g., CCL2, CCL3, CCL4, CCL8, etc.)and proinflammatory cytokines (e.g., TNF-α, IL-1, IL-6, IL-17, etc.). Here, CCL2 is linked to neoplasm.