As MRTFs were found to be involved in promoting tumor cell invasion and metastasis in epithelial cancers, such as pancreatic cancer, it is reasonable to speculate that the MRTF/SRF signaling pathway contributes to the upregulation of SRF expression during the neoplastic process of OSCC, which originates from the epithelium [29]. The gene discussed is SRF; the disease is familial pancreatic carcinoma.