MET overexpression in VHL-deficient ccRCC is associated with an epithelial to mesenchymal transition (EMT) by inducing the expression of beta-catenin, N-cadherin and vimentin (Figure 3) while suppressing the expression of E-cadherin, indicating a potential involvement in metastasis. This evidence concerns the gene CDH2 and nonpapillary renal cell carcinoma.