The activated (phosphorylated) EGFR is more stable in VHL-deficient ccRCC cells compared to pVHL-positive ccRCC cells, since pEGFR is degraded via VHL-mediated proteasomal mechanisms which are significantly attenuated upon VHL loss in ccRCC tumors [77]. The gene discussed is EGFR; the disease is nonpapillary renal cell carcinoma.