SLC2A1 and renal cell carcinoma: HIF-2α induced expression of GLUT-1 is Nox4 dependent since genetic inhibition of Nox4 not only represses HIF-2α transcription but also abrogates GLUT-1 gene induction in 786-O cells, possibly linking NOX4-induced oxidative stress response to the HIF-2α-GLUT1 signaling axis in RCC progression [140].