Kim et al. collected peripheral blood samples from 144 (18.9%—45/237) patients with NSCLC before therapy and discovered low numbers of effector memory CD8+ T cells in the peripheral blood of patients with HPD and increased severe depletion CD8+ T cells with high expression of PD-1 and TIGIT [25]. The gene discussed is CD8A; the disease is non-small cell lung carcinoma.