In addition, pro-inflammatory mediators, including TNF-α and IL-6, prompt a direct pro-angiogenic effect by inducing HIF-1α and VEGF [151], and cytokines and ROS released during NASH can activate the MAPK/ERK pathway, which is involved in cell migration and angiogenesis [29,151]. This evidence concerns the gene HIF1A and metabolic dysfunction-associated steatohepatitis.