NOS3 and metabolic dysfunction-associated steatohepatitis: Within this lipotoxic and inflammatory milieu and compounded by the inhibition of endothelial nitric oxide synthase (eNOS) mediated by liver sinusoidal endothelial cells (LSECs) [29], quiescent hepatic stellate cells (HSCs) differentiate into myofibroblasts which secrete a fibrotic matrix, rich in type I collagen [30,31] in a process of damage and repair which is maladaptive in the chronic state of NASH and thus leads to progressive fibrosis [16].