GPC1 and Familial prostate cancer: Some of these proteins with reduced expression after surgery are EMMPRIN [116], 60 kDa heat shock protein (HSP60) [117], and glypican-1 (GPC1) [118] for CRC, cytoskeleton-associated protein 4 (CKAP4) for PDAC [119], and prostate-specific membrane antigen (PSMA) for prostate cancer [120].