One of the first commercially available tests using sEVs for cancer patient stratification is urine-based and called ExoDx Prostate IntelliScore (EPI), which detects vesicular mRNA levels of prostate cancer antigen 3 (PCA3), ETS transcription factor ERG (ERG), and SAM-pointed domain containing ETS transcription factor (SPDEF). The gene discussed is SPDEF; the disease is cancer.