EGFR and glioblastoma: Further examples of the predictive ability of EV-based cancer biomarkers in other body fluids are vesicular miR-21 in the cerebrospinal fluid of GBM patients, which was associated with poor prognosis and tumor recurrence [145], and EGFR mutations detected by the EV-DNA of NSCLC-derived bronchial wash fluid, which was correlated with disease progression [146].