BSG and cancer: Similarly, extracellular matrix metalloproteinase inducer (EMMPRIN) was detected in high levels in plasma lEVs from cancer patients with different kinds of solid tumors and showed a robust detection efficiency, especially in combination with epithelial cell adhesion molecule (EpCAM), mucin-1 (MUC1), and epidermal growth factor receptor (EGFR) expression rates [23].