PC3 was suggestively inversely associated with the risk of the HER2+ sub-type breast cancer (IVWrandom-effects OR = 0.75 [95% CI: 0.53–1.08]; p-value = 0.122) (Figure 2), in contrast with other sub-types; triple negative and luminal B/HER2 negative sub-types of breast cancer, although risk estimates were imprecise (ORtriple negative = 1.14 [95% CI 0.88–1.48]; ORluminal B/HER2 negative = 1.13 [95% CI 0.88–1.44]) (Figure 2). The gene discussed is ERBB2; the disease is breast cancer.