CDH1 and cancer: While E-cadherin is a notable factor responsible for enhancing IGF-1R stability and plasma membrane localization in cells with low migratory ability and even nonmigratory cells, β-integrin is a meaningful factor for determining IGF-1R translocation to or release from the Golgi apparatus in cancer cells, and its subcellular localization is associated with cancer cell migratory potential and aggressive behaviors [30,62].